Grandma Has Destroyed All Humans
"Look! I get to pick up a cow!! AAAHHAHAHAHAHAA!!!"
"SHE SHIT HERSELF!!! I SHOT HER WITH AN ANAL PROBE AN SHE SHIT HER SELF TO DEATH!!!!"
"You can make the cow do the chicken dance! Dance fucker!!!"
And so on. That is, until she realized the mini-missions are really, incredibly hard. Then she stopped laughing and returned to her normal, cheerful ball of geriatric demons. One point of the game of particular annoyance was when she had to "take the form of the mayor of town and convince people nothing was going on." It's sort of a KOTOR thing where you have several options for dialogue. You could A) Blame it on Communists; B) Say you haven't seen anything strange; C) Blame it on rebellious youth listening to jazz music; or D) Kill them all! She kept saying kill them, and the mission would fail. Grandma would scream in protest.
"You have to blame it on the communists," I'd say.
She'd reply: "But the god damn title is Destroy All Fucking Humans!! It doesn't make sense!!"
Then she would go into a strange, under-the-breath diatribe about how games that were not sold as Metal Gear Solid should not be Metal Gear Solid with "all that sneaking around shit..."
It took her about 16 hours of gameplay to get 100%, which unlocked some B-Movie "Teenagers from Outer Space," which she proceeded to watch in it's entirety. Trying reading about terrorism with that in the background. It really puts everything in perspective.